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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B5
All Species:
32.73
Human Site:
S527
Identified Species:
60
UniProt:
Q13144
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13144
NP_003898.2
721
80380
S527
N
M
E
E
E
S
E
S
E
S
E
Q
S
M
D
Chimpanzee
Pan troglodytes
XP_001139517
721
80405
S527
N
M
E
E
E
S
E
S
E
S
E
Q
S
M
D
Rhesus Macaque
Macaca mulatta
XP_001104122
721
80584
S527
N
M
E
E
E
S
E
S
E
S
E
Q
S
M
D
Dog
Lupus familis
XP_545227
721
80416
T527
N
M
E
E
E
S
E
T
E
S
E
Q
S
M
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8CHW4
717
80068
T523
K
T
E
E
E
S
E
T
E
S
E
G
S
V
D
Rat
Rattus norvegicus
Q64350
716
80188
T522
N
M
E
E
E
S
E
T
E
S
E
R
S
V
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506973
657
73984
Q480
D
S
R
G
G
S
P
Q
L
D
D
I
K
V
F
Chicken
Gallus gallus
XP_422755
716
81293
S511
L
S
E
E
E
S
E
S
D
S
D
L
S
M
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001107069
703
79791
S510
N
P
D
P
E
S
D
S
E
S
E
V
S
E
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784928
1190
133261
S995
E
E
E
E
E
E
E
S
E
E
S
D
D
D
L
Poplar Tree
Populus trichocarpa
XP_002328528
718
80680
D521
D
L
E
F
L
N
L
D
G
N
A
L
S
T
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_181042
730
81845
S511
P
I
P
K
D
K
L
S
E
I
T
Q
A
I
D
Baker's Yeast
Sacchar. cerevisiae
P32501
712
81143
K520
S
A
T
K
K
T
K
K
R
R
T
M
S
V
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.3
93.1
N.A.
88.3
88.3
N.A.
77.2
73.2
N.A.
62.9
N.A.
N.A.
N.A.
N.A.
27.2
Protein Similarity:
100
99.8
99
96.2
N.A.
93.4
93.9
N.A.
83.7
85.3
N.A.
78.5
N.A.
N.A.
N.A.
N.A.
40
P-Site Identity:
100
100
100
93.3
N.A.
66.6
80
N.A.
6.6
60
N.A.
53.3
N.A.
N.A.
N.A.
N.A.
40
P-Site Similarity:
100
100
100
100
N.A.
80
100
N.A.
26.6
73.3
N.A.
66.6
N.A.
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
33.8
N.A.
N.A.
32.7
28.8
N.A.
Protein Similarity:
55.2
N.A.
N.A.
53.2
50
N.A.
P-Site Identity:
13.3
N.A.
N.A.
26.6
6.6
N.A.
P-Site Similarity:
40
N.A.
N.A.
60
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
0
0
0
8
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
16
0
8
0
8
0
8
8
8
8
16
8
8
8
54
% D
% Glu:
8
8
70
62
70
8
62
0
70
8
54
0
0
8
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
0
8
8
0
0
0
8
0
0
8
0
0
16
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
8
0
8
0
8
0
% I
% Lys:
8
0
0
16
8
8
8
8
0
0
0
0
8
0
0
% K
% Leu:
8
8
0
0
8
0
16
0
8
0
0
16
0
0
8
% L
% Met:
0
39
0
0
0
0
0
0
0
0
0
8
0
39
0
% M
% Asn:
47
0
0
0
0
8
0
0
0
8
0
0
0
0
8
% N
% Pro:
8
8
8
8
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
8
0
0
0
39
0
0
0
% Q
% Arg:
0
0
8
0
0
0
0
0
8
8
0
8
0
0
0
% R
% Ser:
8
16
0
0
0
70
0
54
0
62
8
0
77
0
8
% S
% Thr:
0
8
8
0
0
8
0
24
0
0
16
0
0
8
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
8
0
31
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _